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      1. South Africa/
      2. Our innovation /
      3. Focus areas /
      4. Immunology /
      5. Gastroenterology

      Inflammatory Bowel Disease (IBD)

      When it comes to Crohn’s disease or ulcerative colitis, it’s important to remember that you’re not alone. We’re here to support you, and the millions of other sufferers around the world, by tackling the chronic inflammation that makes inflammatory bowel disease so stressful to live with.
      Our focus areas
      IBD is believed to be caused by a combination of factors, including your genes, an abnormal reaction of your immune system to certain bacteria in your gut, and triggers to do with diet or stress.[1], [2], [3] IBD is not the same as irritable bowel syndrome (IBS), which is a non-inflammatory condition.[1]

      We’re focused on the two main types of IBD: Crohn’s disease and ulcerative colitis.
      JNJ_BodyIllustration_Interior_Organ_StomachEsophagus_Colorway02
      Crohn’s Disease (CD)
      Crohn’s disease is a chronic condition affecting any region of the gastrointestinal tract. It’s characterised by the body’s immune system mistaking food, bacteria and other materials in the intestine for foreign substances.[2], [4]
      JNJ_BodyIllustration_Interior_Organ_Colon_Colorway01b
      Ulcerative Colitis (UC)
      Ulcerative colitis is a chronic inflammation of the rectum and large intestine (the colon). Ulcers develop on the lining of the large intestine and these may bleed and produce mucus.[5]

      References:

      [1] Centers for Disease Control and Prevention: What is inflammatory bowel disease? Available at: https://www.cdc.gov/inflammatory-bowel-disease/?CDC_AAref_Val=https://www.cdc.gov/ibd/what-is-IBD.html. Accessed November 2020.
      [2] Crohn’s & Colitis UK. What is Ulcerative Colitis? Available at: https://crohnsandcolitis.org.uk/info-support/information-about-crohns-and-colitis/all-information-about-crohns-and-colitis/living-with-crohns-or-colitis?parent=23174&page=1&tags=&category=23174&sort=newest. Accessed November 2020.
      [3] Qingdong G. A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease. J Immunol Res. 2019; 2019:7247238
      [4] Torres J, et al. Crohn’s disease. Lancet. 2017 Apr 29;389(10080):1741-1755.
      [5] Ungaro R, et al. Ulcerative colitis. Lancet. 2017 Apr 29;389(10080):1756-1770

      CP-497734 | January 2025