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      Home/Newsroom/Immunology

      Immunology latest news

      The first and only dual-acting interleukin-23 inhibitor approved in active ulcerative colitis, TREMFYA® showed highly statistically significant rates of endoscopic remission at one year in the pivotal QUASAR program1,2,3,4,5

      TREMFYA® is now approved for the treatment of plaque psoriasis, active psoriatic arthritis and ulcerative colitis
      NM26 is a Phase 2-ready, first-in-class bispecific antibody targeting two clinically proven pathways in atopic dermatitis (AD)

      The Company is leveraging a multi-pathway approach to transform treatment in atopic dermatitis and other immune-mediated diseases
      First-and-only FcRn blocker to demonstrate superiority in activities of daily living (MG-ADLa) over placebo when added to standard of care over 24 weeks in antibody positive patients: anti-AChR+, anti-MuSK+, anti-LRP4+
      The Phase 3 AZALEA and Phase 3 FREESIA clinical studies are enrolling pregnant individuals who are at risk for severe HDFN and FNAIT

      These rare and potentially life-threatening alloantibody diseases affecting pregnant individuals and their fetus or newborn currently have no approved treatments
      Submission is supported by 48-week results from the Phase 3 GALAXI and GRAVITI programs

      TREMFYA® is the only IL-23 inhibitor to demonstrate strong endoscopic outcomes with subcutaneous (SC) induction, consistent with intravenous (IV) induction, and has the potential to be the first in its class to offer the option of both SC and IV induction therapy in Crohn’s disease

      GALAXI includes data demonstrating superior outcomes for TREMFYA® versus STELARA® (ustekinumab) in Crohn’s disease
      Patients who received nipocalimab 15 mg/kg demonstrated a greater than 70 percent relative average improvement on the primary endpoint compared to patients who received placebo

      Sjögren’s disease is a chronic, debilitating, and prevalent autoantibody disease with no approved advanced treatments
      30 abstracts highlight the company’s robust portfolio and commitment to improving outcomes for patients with immune-mediated diseases


      Features positive results from a Phase 2 study of nipocalimab in Sjögren’s disease as a late-breaking oral presentation
      The Company1 enters agreement with Numab Therapeutics to acquire its wholly owned subsidiary2 for the global rights to NM26, a Phase 2-ready investigational, first-in-class bispecific antibody targeting two clinically proven pathways in atopic dermatitis (AD)

      NM26 has the potential to offer distinctive benefits versus existing treatments and address key unmet needs for AD patientsJ

      ohnson & Johnson is committed to developing differentiated bispecific antibodies for treating AD and other immune-mediated diseases