Bacterial infections
We are working urgently to help protect society from the consequences of extraintestinal pathogenic E. coli (ExPEC) and Staphylococcus aureus (S. aureus or staph) infections, including Methicillin-resistant S. aureus (MRSA) and other bacteria that cause bacterial lung infections, such as Pseudomonas aeruginosa.[1]
In 2017, an estimated 48.9 million incident cases of sepsis and 11 million sepsis-related deaths were reported worldwide, representing almost 20% of all global deaths.[3]
As the primary cause of urinary tract infections, which can account for 25% of antibiotic prescriptions, ExPEC is considered a major driver behind the global AMR crisis [8],[9],[10]”
References
[1]Smith D and Nehring S. Bacteremia. Stat Pearls Publishing. 2019.
[2]Ramachandran G. Gram-positive and gram-negative bacterial toxins in sepsis - A brief review. Virulence. 2014; 5(1):213-218.
[3]Rudd et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. Lancet. 2020; 395: 200–11.
[4]Dadgostar P. Antimicrobial Resistance: Implications and Costs. Infect Drug Resist. 2019;12:3903-3910.
[5]Prestinaci, F., et al. Antimicrobial resistance: a global multifaceted phenomenon. Pathogens and global health. 2015;109(7):309–318.
[6]World Health Organization. Ten threats to global health in 2019. Available at:
https://www.who.int/vietnam/news/feature-stories/detail/ten-threats-to-global-health-in-2019. Accessed: December 2022.
[7]Review on antimicrobial resistance. Tackling drug-resistant infections globally: Final report and recommendations. Available at:
https://amr-review.org/sites/default/files/160525_Final%20paper_with%20c... Accessed: December 2022.
[8]Singer RS,. Urinary tract infections attributed to diverse ExPEC strains in food animals: evidence and data gaps. Front Microbiol. 2015;6:28
[9]Sihra N. Nonantibiotic prevention and management of recurrent urinary tract infection. Nat Rev Urol. 2018;15(12):750–776.
[10]Longitude prize. 10 most dangerous antibiotic-resistant bacteria. Available at:
https://longitudeprize.org/blog-post/10-most-dangerous-antibiotic-resist.... Accessed: December 2022.
[11]World Health Organization. Antibiotic resistance. Available at:
https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance. Accessed: December 2022.
CP-459038
September 2024