Bladder cancer
To do this, we are developing targeted therapies and deepening our understanding of this complex disease.
Since the mid – to late 1990s, in many European nations incidence rates of bladder cancer have continued to rise, with the highest rate in Southern Europe, for both men and women. [5]
Mortality rates in European men were by far the highest recorded worldwide, with the highest mortality in Western Europe. [6]
We are focusing on better understanding the drivers of urothelial cancer, the most common type of bladder cancer [9] and are exploring targeted therapies - alone and in combination - to transform outcomes. [10] At Johnson & Johnson Oncology, average isn’t good enough. We’re driven only to deliver the best outcomes to patients, partners, and the oncology community.
We see enormous potential in the use of companion diagnostics, to ensure patients have access to the latest and most appropriate therapeutic opportunities.
Recent research efforts in the field of precision oncology have provided key insights that have transformed the treatment paradigm, and will undoubtedly continue to expand our therapeutic options in the years to come.
[11]
We believe that the TARIS bladder-specific drug-delivery platform has the potential to be transformative in delivering active treatments locally with the ability to combine with systemic therapies to develop regimens for early stage non-muscle and muscle invasive bladder cancer patients. [10] [12]
References
[1] IARC. Online analysis table. Available at:
https://gco.iarc.fr/today/online-analysis-table?v=2020&mode=cancer&mode_... . Accessed October 2022.
[2] European Cancer Patient Coalition. Bladder Cancer Awareness Month Campaign. Available at:
https://ecpc.org/get-involved/bladder-cancer-awareness-month-campaign/. Accessed October 2022
[3] Cancer.org. Can Bladder Cancer Be Found Early? Available at:
https://www.cancer.org/cancer/bladder-cancer/detection-diagnosis-staging... Accessed October 2022
[4] Cancer.net. Bladder Cancer: Statistics. Available at:
https://www.cancer.net/cancer-types/bladder-cancer/statistics. Accessed October 2022
[5] Saginala K, Barsouk A, Aluru JS, Rawla P, Padala SA, Barsouk A. Epidemiology of Bladder Cancer. Med Sci (Basel). 2020 Mar 13;8(1):15. doi: 10.3390/medsci8010015. PMID: 32183076; PMCID: PMC7151633.
[6] Globocan 2020.
https://gco.iarc.fr/today/online-analysis-dual-bars-2?v=2020&mode=cancer.... Accessed October 2022
[7] American Cancer Society. Key Statistics for Bladder Cancer. Available at:
https://www.cancer.org/cancer/bladder-cancer/about/key-statistics.html#:.... Accessed October 2022.
[8] European Cancer Patient Coalition. Urological Cancer. Available at:
https://ecpc.org/news-events/bladder-cancer/. Accessed October 2022.
[9] Macmillan. Types of bladder cancer. Available at:
https://www.macmillan.org.uk/cancer-information-and-support/bladder-canc.... Accessed October 2022.
[10] Clinicaltrials.gov. Janssen in urothelial carcinoma. Available at:
https://clinicaltrials.gov/ct2/results?cond=erdafitinib+OR+tar-200+OR+ce.... Accessed October 2022.
[11] Liow E, Tran B. Precision oncology in urothelial cancer. ESMO Open 2020;5:e000616.
[12] Janssen. Johnson & Johnson Acquires TARIS Biomedical with Focus on Transforming the Treatment of Bladder Cancer. Available at:
https://johnsonandjohnson.gcs-web.com/static-files/144c992a-c2c0-4180-b8... Last accessed October 2022.
[13] Cancer.org. Types of B-cell Lymphoma. Available at:
https://www.cancer.org/cancer/non-hodgkin-lymphoma/about/b-cell-lymphoma.... Last accessed October 2022.
[14] HEAL. Men Prostate cancer. Available at
https://www.env-health.org/IMG/pdf/prostate_testical.pdf. Accessed March 2021.
[15] Cancer.Net. Lung Cancer - Non-Small Cell: Statistics. Available at
https://www.cancer.net/cancer-types/lung-cancer-non-small-cell/statistics. Accessed June 2021.
CP-459038
September 2024