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      EMEA/Our innovation /Focus areas/Oncology /Prostate cancer/Transforming cancer’s trajectory

      Transforming cancer’s trajectory

      There is no universal approach to cancer treatment, which is why we are committed to understanding the differences in patients’ clinical and non-clinical characteristics and how this can impact the therapeutic benefit of our medicines.[14]

      We are pioneering a cutting-edge approach to our scientific methodologies and technologies[15], which enables us to adapt our discovery and development initiatives to drive our next wave of innovation.[4],[5]

      We are pushing the boundaries of our understanding of prostate cancer and unlocking innovative ways to tackle it before it progresses. When it comes to treating cancer, it’s long been known that catching the disease in its early stages is key for a more successful outcome.[15] The premise behind the new strategy, which aims to halt or prevent cancer, is to understand why some healthy cells turn cancerous, so medications can be developed to interrupt that process – and potentially thwart the disease before it invades the body.[16]

      What’s more, we have more than 30 years’ experience in oncology, and our commitment to innovation runs deeply within everyone at Johnson & Johnson Oncology.[17] We put our focus where we can make the most meaningful difference. We’re driven only to deliver the best outcomes to patients, partners, and the oncology community.

      [1] IARC. Online analysis table. Available at: https://gco.iarc.fr/today/online-analysis-pie?v=2020&mode=cancer&mode_po.... Accessed January 2023.

      [2] Smith-Palmer et al. Literature review of the burden of prostate cancer in Germany, France, the United Kingdom and Canada. BMC Urology. 2019 19, 19.

      [3] European Medicines Agency. Zytiga authorisation details. Availabe at: https://www.ema.europa.eu/en/medicines/human/EPAR/zytiga#authorisation-details-section. Accessed February 2023

      [4] European Medicines Agency. ERLEADA Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/9832/smpc#gref. Accessed December 2022.

      [5] European Medicines Agency. ZYTIGA Summary of Product Characteristics. Available at: https://www.ema.europa.eu/en/documents/product-information/zytiga-epar-product-information_en.pdf. Accessed June 2021.

      [6] Hait, W.N. et al. Moving upstream in anticancer drug development. Nat Rev. 2018; 18: 159-160

      [7] Delgado, A, et al. Clinical endpoints in oncology - a primer. Am J Cancer Res. 2021; 11 (4): 1121-1131

      [8] Golden Gate Cancer Center. Men with newly diagnosed prostate cancer – a primer. Available at:https://www.goldengatecancercenter.com/blog/men-with-newly-diagnosed-prostate-cancer-a-primer. Accessed January 2023.

      [9] European Federation of Pharmaceutical Industries and Associations. Precision Medicine. Availabe at: https://www.efpia.eu/about-medicines/development-of-medicines/precision-medicine/#:~:text=%E2%80%9CPrecision%20medicine%20is%20a%20healthcare,resulting%20in%20improved%20health%20outcomes%E2%80%9D. Accessed February 2023

      [10] ClinicalTrials.gov. A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer (MAGNITUDE). Availabe at: https://clinicaltrials.gov/ct2/show/NCT03748641?term=niraparib++magnitude&draw=2&rank=1 Accessed February 2023

      [11] The Pharmaceutical Journal. The precision medicine approach to cancer therapy. Available at: https://pharmaceutical-journal.com/article/research/the-precision-medicine-approach-to-cancer-therapy-part-1-solid-tumours Accessed January 2023

      [12] John Hopkins. Prostate Cancer Prognosis. Available at: https://www.hopkinsmedicine.org/health/conditions-and-diseases/prostate-cancer/prostate-cancer-prognosis. Accessed January 2023

      [13] Cancer.net. Prostate Cancer: Statistics. Available at: https://www.cancer.net/cancer-types/prostate-cancer/statistics. Accessed January 2023

      [14] Seyhan, A.A., Carini, C. Are innovation and new technologies in precision medicine paving a new era in patients centric care?. J Transl Med 2019;17:114

      [15] ClinicalTrials.gov. An Efficacy and Safety Study of JNJ-56021927 (Apalutamide) in High-risk Prostate Cancer Subjects Receiving Primary Radiation Therapy: ATLAS. Availabe at: https://clinicaltrials.gov/ct2/show/NCT02531516?term=erleada+atlas&draw=2. Accessed February 2023

      [16] American Association for Cancer Research. Intercepting Cancer by Tackling Precancer. Available at: https://www.aacr.org/blog/2021/01/15/intercepting-cancer-by-tackling-precancer/. Accessed January 2023

      [17] Clinicaltrials.gov. Molecular Studies and Clinical Correlations in Human Prostatic Disease. Available at: https://clinicaltrials.gov/ct2/show/NCT00578240. Accessed January 2023

      [18] Smith, R, M, et al. Relationship Between Metastasis-free Survival and Overall Survival in Patients With Nonmetastatic Castration-resistant Prostate Cancer. Clinical Genitourinary Cancer. 2019; 18: 180-9

      [19] Carles, J. et al. ORACULUM. A Retrospective Observational Epidemiological Study Using Artificial Intelligence and Natural Language Processing in Electronic Health Records to Characterize the Prostate Cancer pathway, Management and Outcomes in Europe, Middle East and Africa (EMEA region). Poster presentation at the European Society for Medical Oncology Virtual Congress, September 2020 (abstract #695TiP).

      [20] Astex. Astex Announces New Drug Discovery Alliance with Janssen Pharmaceutica N.V. Available at: https://astx.com/wp-content/uploads/2016/11//ASTX_News_2008_6_9_General_Releases.pdf. Accessed January 2023

      [21] Ahuja AS. The impact of artificial intelligence in medicine on the future role of the physician. PeerJ. 2019;7:e7702.

      [22] MELLODDY. MELLODDY Project meets its year one objective: deployment of the world’s first secure platform for multi-task federated learning in drug discovery among 10 pharmaceutical companies. Available at: https://www.melloddy.eu/y1announcement. Accessed January 2023

      [23] WebMD. What Is B-Cell Lymphoma. Available at: https://www.webmd.com/cancer/lymphoma/what-is-b-cell-lymphoma. Accessed January 2023

      [24] Zhang, et al. Clinicopathological factors in bladder cancer for cancer-specific survival outcomes following radical cystectomy: a systematic review and meta-analysis. Available at: https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-5924-6. Accessed January 2023

      [25] World Bladder Cancer Patient Coalition. Annual Meeting Report 2020. Available at: https://worldbladdercancer.org/wp-content/uploads/2020/11/WBCPC-Annual-Meeting-2020-Report.pdf. Accessed January 2023

      [26] Cancer.Net. Lung Cancer - Non-Small Cell: Statistics. Available at:https://www.cancer.net/cancer-types/lung-cancer-non-small-cell/statistics. Accessed January 2023